Reduced glomerular filtration rate in individuals with intermediate hyperglycemia and type 2 diabetes as defined by 1-hour post-load glucose levels according to the newly released International Diabetes Federation (IDF) criteria
Authors' conclusion
The 1 h-PG thresholds proposed by IDF as diagnostic for IH and T2DM are capable of identifying individuals at risk of kidney dysfunction.
Study context
- Population
- Subjects classified by fasting, 1 h and 2 h post-load glucose according to IDF criteria
- Participants
- 2,161 subjects
- Exposure
- Glucose tolerance categories by IDF criteria vs normal glucose tolerance (NGT)
- Outcome
- CKD (eGFR < 60 ml/min/1.73 m²)
Main finding
As reported in the abstract
Each group vs NGTOdds ratio (95% CI)P value
iIFG
3.48(1.01–11.00)
P = 0.05IH
3.69(1.42–9.60)
P = 0.007T2DM
3.93(1.36–10.66)
P = 0.007Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Mildly reduced kidney function (eGFR 90-60 ml/min/1.73 m²)IHvs NGT | 1.89 (1.38–2.60) | P < 0.0001 | |
| Mildly reduced kidney function (eGFR 90-60 ml/min/1.73 m²)T2DMvs NGT | 2.78 (1.97–3.98) | P < 0.0001 | |
| 0.20.5125Odds ratio (log scale) |
Mildly reduced kidney function (estimated glomerular filtration rate (eGFR) 90-60 ml/min/1.73 m²)
- Prevalence progressively increased at worsening of glucose tolerance
Original publication
Reduced glomerular filtration rate in individuals with intermediate hyperglycemia and type 2 diabetes as defined by 1-hour post-load glucose levels according to the newly released IDF criteria. Diabetes Res Clin Pract. Published 5 March 2025. doi:10.
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