Risk of coronary artery disease in intermediate hyperglycemia and type 2 diabetes defined by 1-hour post-load glucose levels according to the new International Diabetes Federation (IDF) criteria
Authors' conclusion
The IDF-recommended 1hPG criterion for defining IH and T2D identifies subjects with an increased odds of CAD, independent of other cardiovascular risk factors.
Study context
- Population
- Adults classified per IDF recommendation by glucose tolerance
- Participants
- 3,362 adults
- Exposure
- Intermediate hyperglycemia (IH) and T2D vs normal glucose tolerance (NGT)
- Outcome
- Presence of coronary artery disease (CAD)
Main finding
As reported in the abstract
CAD
Adjusted odds (fold higher)
2.52
IH
Adjusted odds (fold higher)
2.05
T2D
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| CAD by IH/T2D subdivision (1hPG, 2hPG)Isolated 1hPG 155-208 mg/dL vs NGT | odds (fold increased) 2.8 |
| CAD by IH/T2D subdivision (1hPG, 2hPG)2hPG 140-199 mg/dL vs NGT | odds (fold increased) 2.21 |
| CAD by IH/T2D subdivision (1hPG, 2hPG)T2D by isolated 1hPG ≥ 209 mg/dL vs NGT | OR 2.0 |
| CAD by IH/T2D subdivision (1hPG, 2hPG)T2D by 2hPG ≥ 200 mg/dL vs NGT | OR 2.28 |
Original publication
Risk of coronary artery disease in intermediate hyperglycemia and type 2 diabetes defined by 1-hour post-load glucose levels according to the new IDF criteria. Diabetes Res Clin Pract. Published 11 January 2026. doi:10.
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