Pathophysiological characteristics of subjects with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test
Authors' conclusion
1-h PG-based criteria for diagnosis of IH and diabetes identify individuals having an unfavorable cardiometabolic risk profile with a progressive reduction in insulin sensitivity associated with impaired β cell function.
Study context
- Population
- Individuals stratified by fasting, 1-hour and 2-hour plasma glucose during an oral glucose tolerance test (OGTT)
- Participants
- 3,086 individuals
- Exposure
- Intermediate hyperglycemia (IH) and newly diagnosed T2D vs normal glucose tolerance (NGT) and isolated IFG
- Outcome
- Cardiometabolic characteristics
Main finding
As reported in the abstract
- IH and T2DM vs NGT: higher adiposity, blood pressure, uric acid, worse lipid and inflammatory profile, progressive reduction in Matsuda index, insulinogenic index and disposition index
- IH and T2DM vs iIFG: lower Matsuda, insulinogenic and disposition indexes
Observational data: associations, not effects.
Original publication
Pathophysiological characteristics of subjects with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test. Diabetes Res Clin Pract. Published 10 September 2024. doi:10.
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