Relationship Between Radiation Dose and Markers of Insulin Resistance and Inflammation in Atomic Bomb Survivors
Authors' conclusion
Insulin resistance might be a possible factor in radiation-related diabetes incidence in A-bomb survivors.
Study context
- Population
- A-bomb survivors younger than 15 years at exposure who underwent a health examination between 2008 and 2012
- Participants
- 3,152 participants
- Exposure
- Radiation dose and markers of inflammation and insulin resistance
- Outcome
- Levels of markers of inflammation and insulin resistance by radiation dose
Main finding
As reported in the abstract
- Radiation dose significantly and positively associated with C-reactive protein, TG, HOMA-β and HOMA of insulin resistance (HOMA-IR) (adjusted for sex, city, age at exposure)
- Adiponectin and HDL-C significantly and negatively associated with radiation dose
- City was not a dose modifier of the radiation response on these markers
- Multivariate linear regression
Observational data: associations, not effects.
Original publication
Relationship Between Radiation Dose and Markers of Insulin Resistance and Inflammation in Atomic Bomb Survivors. J Clin Endocrinol Metab. Published 10 September 2024. doi:10.
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