Identification of oral microbial biomarkers for prediabetes in young adults: A two-stage population-based study
Authors' conclusion
Reproducible alterations and enrichment of Prevotella_7 and Veillonella are linked to prediabetes in young adults. Furthermore, the combined interaction between specific bacterial genera and core clinical indicators may be crucial in the development of prediabetes in young individuals.
Study context
- Population
- Young adults from two independent cohorts; discovery cohort 334 prediabetes cases and 1,266 controls, validation cohort 325 prediabetes cases and 1,217 controls
- Participants
- 3,142 adults2 cohorts
- Exposure
- Prediabetes vs normoglycemic controls
- Outcome
- Oral microbial signatures of prediabetes
Methodological detailstwo-stage, population-based, discovery and validation cohorts, 16S rRNA gene sequencing of oral rinse samples
- Two-stage
- Population-based
- Discovery and validation cohorts
- 16S rRNA gene sequencing of oral rinse samples
Main finding
As reported in the abstract
- Prediabetes-enriched taxa: Bacteroidetes, Prevotella_7 and Veillonella
- Higher presence of Firmicutes and Streptococcus in normoglycemic controls
Observational data: associations, not effects.
Further findings
Discrimination of combined models (LASSO-selected BMI, HOMA-IR and Prevotella_7 or Veillonella)
- AUC, discovery set, Prevotella_7 model
- 0.761
- AUC, discovery set, Veillonella model
- 0.758
- AUC, validation set, Prevotella_7 model
- 0.693
- AUC, validation set, Veillonella model
- 0.696
Original publication
Identification of oral microbial biomarkers for prediabetes in young adults: A two-stage population-based study. Diabetes Res Clin Pract. Published 11 January 2026. doi:10.
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