High one-hour plasma glucose is an intermediate risk state and an early predictor of type 2 diabetes in a longitudinal Korean cohort
Authors' conclusion
High 1h-PG NGT is an intermediate risk category between Low 1h-PG NGT and PreDM and may provide an opportunity for early intervention to prese rve ß-cell function.
Study context
- Population
- Korean Genome Epidemiology study participants with OGTTs every 2 years over 10 years
- Participants
- 6,144 participants
- Exposure
- High 1h-PG Normal Glucose Tolerance (NGT) and PreDM vs Low 1h-PG NGT
- Outcome
- Risk of T2D by baseline 1h-PG
- Follow-up
- 10 years
Methodological details10-year follow-up, OGTTs every 2 years
- 10-year follow-up
- OGTTs every 2 years
Main finding
As reported in the abstract
T2D risk
- T2D risk higher with High 1h-PG NGT and PreDM than with Low 1h-PG NGT
Observational data: associations, not effects.
Further findings
Baseline insulin sensitivity (insulin sensitivity and secretion (ISS) model, Matsuda insulin sensitivity index (ISI))
- Higher in Low 1h-PG than High 1h-PG; High 1h-PG comparable to PreDM
β-cell function (ISS, insulinogenic index)
- Decreased from Low 1h-PG to High 1h-PG to PreDM
Insulin sensitivity over time
- Decreased in all three groups
Time to T2D
- Shorter from High 1h-PG than from Low 1h-PG
- 0.9 years
1h-PG thresholds passed first before T2D
- Passed 1h-PG threshold for T2D (209 mg/dL, 11.6 mmol/L) first
- All participants
- Passed 1h-PG threshold for impaired glucose tolerance (IGT) (155 mg/dL) first
- 74 %
Original publication
High one-hour plasma glucose is an intermediate risk state and an early predictor of type 2 diabetes in a longitudinal Korean cohort. Diabetes Res Clin Pract. Published 29 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →