The association between index-year, average, and variability of the triglyceride-glucose index with health outcomes: more than a decade of follow-up in Tehran lipid and glucose study
Authors' conclusion
Although the higher TyG index at index-year and its VVV were only associated with the incident T2DM and hypertension, respectively, its average value was capable of capturing the risk for all of the health outcomes.
Study context
- Population
- Iranian adults aged ≥30 years, Tehran lipid and glucose study; TyG index exposure period 2002–20112,195 men
- Participants
- 5,220 adults
- Exposure
- Index-year, average and visit-to-visit variability of the TyG index
- Outcome
- Incident T2D, hypertension, CVD and all-cause mortality
- Follow-up
- More than 6 years after the index year
Methodological detailspopulation-based, multivariable Cox proportional hazards regression
- Population-based
- Multivariable Cox proportional hazards regression
Main finding
As reported in the abstract
Incident outcomes per 1-SD increase in TyG index · more than 6 years of follow-up
- Events: T2D
- 290
- Events: hypertension
- 560
- Events: Cardiovascular disease (CVD)
- 361
- Events: all-cause mortality
- 280
- Index-year TyG index, incident T2D, HR
- 2.50 (2.13-2.93) (95% CI)
- Average TyG index, incident T2D, HR
- 2.37 (2.03-2.76) (95% CI)
- Average TyG index, incident hypertension, HR
- 1.12 (0.99-1.26, pvalue = 0.05) (95% CI)
- Average TyG index, incident CVD, HR
- 1.18 (1.01-1.36) (95% CI)
- Average TyG index, all-cause mortality, HR
- 1.29 (1.08-1.53) (95% CI)
- Visit-to-visit variability (VVV) of TyG index, tertile 3 vs first tertile, incident hypertension, HR
- 1.33 (1.07-1.64), Ptrend <0.01 (95% CI)
- VVV of TyG index per 1-SD increase, incident hypertension, HR (95% CI); 11% excess risk
- 1.11 (1.02-1.21)
Observational data: associations, not effects.
Further findings
Effect modification by sex, incident CVD
- Impact of index-year and average TyG index more prominent among women for incident CVD
- P for interactions < 0.05
Original publication
The association between index-year, average, and variability of the triglyceride-glucose index with health outcomes: more than a decade of follow-up in Tehran lipid and glucose study. Cardiovasc Diabetol. Published 31 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →