Unveiling glycaemic variability patterns linked to the triglyceride‐glucose index in type 2 diabetes: Insights from continuous glucose monitoring
Main finding · Severe variability glucotypeResult — go to the resultOdds ratio 1.87 95% CI 1.42–2.50Authors' conclusion
Elevated TyG identifies a distinct glycaemic phenotype characterized by high-level, low-frequency oscillations, sustained hyperglycaemia, and minimal hypoglycaemic risk. T2DM patients with high TyG levels may be appropriate candidates for more intensified glucose-lowering strategies.
Study context
- Population
- T2D patients undergoing 14-day continuous glucose monitoring (CGM), community hospitals in Ningbo, China
- Participants
- 279 patients
- Exposure
- TyG tertiles
- Outcome
- Association between TyG and glycaemic variability phenotypes (glucotypes)
Methodological detailscommunity hospitals
- Community hospitals
Main finding
Severe variability glucotype
Odds ratio
1.87
95% CI 1.42–2.50
P < 0.001
TyG
OR 1.87 (95% CI 1.42–2.50); P < 0.001
As reported in the abstract
- Prevalence of severe variability glucotype increased across higher TyG tertiles
- 32.3% to 53.8% to 63.4%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| TAR | P < 0.001 |
- HbA1c across TyG tertiles — Progressive increase in HbA1c across TyG tertiles
- 6.8 ± 1.5%, 7.2 ± 1.2%, 7.3 ± 1.3% · P = 0.011
- Fasting glucose across TyG tertiles — Progressive increase in fasting glucose across TyG tertiles
- 6.1 ± 1.1, 7.2 ± 1.6, 8.5 ± 2.8 mmol/L · P < 0.001
- TG across TyG tertiles — Progressive increase in TG across TyG tertiles
- 0.9 ± 0.2, 1.4 ± 0.4, 2.7 ± 1.0 mmol/L · P < 0.001
- TIR — Lower TIR in the highest TyG tertile
- 81.8% to 72.8 to 70.3% · P = 0.001
- TBR — Paradoxically reduced TBR in the highest TyG tertile
- 2.3% to 1.4% to 0.6% · P = 0.014
- CV — Paradoxically reduced CV in the highest TyG tertile
- 26.2% to 25.8% to 23.8% · P = 0.021
TAR
- Elevated TAR in the highest TyG tertile
Frequency domain analysis
- Elevated TyG associated with high-level, low-frequency glucose oscillations
Original publication
Unveiling glycaemic variability patterns linked to the triglyceride‐glucose index in type 2 diabetes: Insights from continuous glucose monitoring. Diabetes Obes Metab. Published 18 February 2026. doi:10.
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