Low C-Reactive Protein Alleles in Hepatocyte Nuclear Factor 1A Are Associated With an Increased Risk of Cardiovascular Disease
Authors' conclusion
Our study revealed an association between low CRP alleles in HNF1A and a high CVD risk, which indicated that antidiabetic drugs with CV benefits such as glucagon-like peptide-1 receptor agonists should be recommended as a first-line choice for HNF1A-MODY.
Study context
- Population
- Studies of association of HNF1A with C-reactive protein (CRP), cardiovascular disease (CVD), lipids and T2D (PubMed, Embase, Cochrane Library, inception to December 2023)
- Comparison
- Low CRP alleles in HNF1A vs other alleles
- Outcome
- CVD
Pooled result
As reported in the abstract
CVD risk
Low CRP alleles associated with increased CVD risk, OR
1.03 (1.03-1.04) (95% CI)
Further pooled results
Low CRP levels by minor allele (rs1169288, rs2464196, rs1169289)
- rs1169288, OR
- 0.89 (0.86-0.91) (95% CI)
- rs2464196, OR
- 0.89 (0.88-0.91) (95% CI)
- rs1169289, OR
- 0.89 (0.88-0.91) (95% CI)
Higher LDL-C levels
- Low CRP alleles, OR
- 1.07 (1.04-1.10) (95% CI)
T2D risk
- Low CRP alleles, OR
- 1.04 (1.01-1.08) (95% CI)
Original publication
Low C-Reactive Protein Alleles in Hepatocyte Nuclear Factor 1A Are Associated With an Increased Risk of Cardiovascular Disease. J Clin Endocrinol Metab. Published 30 August 2024. doi:10.
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