Insulin Resistance–Adiposity Burden and Incident Cardiovascular Disease Across Glycaemic Transitions in Prediabetes: Risk Stratification After Reversion to Normoglycaemia
Authors' conclusion
Glycaemic transition status did not fully stratify subsequent CVD risk. Cumulative TyG-related measures further stratified CVD risk across glycaemic transition groups, including among participants who reverted to normoglycaemia.
Study context
- Population
- Adults with prediabetes, China Health and Retirement Longitudinal Study; glycaemic transition and triglyceride-glucose (TyG)-derived indices (TyG, TyG-ABSI, TyG-BRI, TyG-CVAI, TyG-WWI) assessed Wave 1 to Wave 3294 cardiovascular disease (CVD) events
- Participants
- 1,468 adults
- Exposure
- Glycaemic transition (reversion to normoglycaemia, progression to diabetes) vs persistent prediabetes, and cumulative TyG-derived indices
- Outcome
- Incident CVD
- Follow-up
- Waves 3 to 5; median 5.0-year follow-up
Methodological detailsChina Health and Retirement Longitudinal Study, exploratory k-means clustering
- China Health and Retirement Longitudinal Study
- Exploratory k-means clustering
Main finding
As reported in the abstract
Incident CVD by glycaemic transition · median 5.0-year follow-up
Each group vs persistent prediabetesHazard ratio (95% CI)
Reversion to normoglycaemia
0.97(0.72–1.31)
Progression to diabetes
1.53(1.14–2.07)
Observational data: associations, not effects.
Further findings
Joint analyses: reversion with low vs high cumulative TyG-derived indices
- Reversion with high indices associated with elevated risk for most indices (hazard ratios (HRs))
- 1.55-2.05
- Reversion with low cumulative indices not associated with increased CVD risk
CVD risk with high cumulative TyG-derived indices among participants who reverted to normoglycaemia
- High cumulative TyG-derived indices associated with higher CVD risk (adjusted HRs; all p < 0.05)
- 1.89-2.52
Change-pattern analyses
- Change-pattern analyses were concordant
Original publication
Insulin Resistance–Adiposity Burden and Incident Cardiovascular Disease Across Glycaemic Transitions in Prediabetes: Risk Stratification After Reversion to Normoglycaemia. Diabetes Obes Metab. Published 25 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →