Association between the triglyceride glucose-Chinese visceral adiposity index and new-onset stroke risk: a national cohort study

Wang, M; Gao, B; Huang, F

doi:10.1186/s12933-025-02668-x

Type 2 & other diabetes

Association between the triglyceride glucose-Chinese visceral adiposity index and new-onset stroke risk: a national cohort study

Cardiovasc DiabetolPublished 12 Mar 2025Prospective cohort study

Main finding · New-onset strokeResultOdds ratio 3.16 95% CI 1.94–5.22

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Authors' conclusion

The fluctuations in and baseline, and cumulative TyG-CVAI index are independently correlated with an increased risk of stroke. The TyG-CVAI index is anticipated to be a more efficient and significant indicator for evaluating early stroke.

Study context

Population: Participants in the China Health and Retirement Longitudinal Study (CHARLS)
Participants: 3,769 participants

Exposure: TyG-CVAI trajectory clusters and quartile-type groups of cumulative and baseline TyG-CVAI
Outcome: New-onset stroke

Methodological detailsnational cohort, K-means clustering, logistic regression, restricted cubic splines

National cohort
K-means clustering
Logistic regression
Restricted cubic splines

Main finding

As reported in the abstract

Odds ratio

3.16

95% CI 1.94–5.22

By group

Cluster 12.42%

Cluster 28.72%

Cluster 34.37%

Cluster 2

OR 3.16 (95% CI 1.94–5.22)

Stroke events during follow-up: 181

Observational data: associations, not effects.

Further findings

New-onset stroke by cumulative TyG-CVAI

	← Lower odds ←→ Higher odds →	OR (95% CI)
Q3 (high cumulative TyG-CVAI)Adjusted for confounding factors	0.20.5125	2.53 (1.60–4.02)
	0.20.5125Odds ratio (log scale)

New-onset stroke by baseline TyG-CVAI

	← Lower odds ←→ Higher odds →	OR (95% CI)
Q3 (high baseline TyG-CVAI)Adjusted for confounding factors	0.20.5125	2.49 (1.57–3.95)
	0.20.5125Odds ratio (log scale)

New-onset stroke by cumulative TyG-CVAI

U-shaped relationship between cumulative TyG-CVAI and stroke risk (restricted cubic splines (RCS))

New-onset stroke by baseline TyG-CVAI

U-shaped relationship between baseline TyG-CVAI and stroke risk (RCS)

Original publication

Association between the triglyceride glucose-Chinese visceral adiposity index and new-onset stroke risk: a national cohort study. Cardiovasc Diabetol. Published 12 March 2025. doi:10.1186/s12933-025-02668-x

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