The interaction between triglyceride-glucose index and visceral adiposity in cardiovascular disease risk: findings from a nationwide Chinese cohort
Authors' conclusion
This study suggests that the interaction between IR (TyG index) and visceral fat accumulation (CVAI) plays a complex role in CVD risk, with a potential antagonistic effect observed between high TyG and high CVAI on CVD events. These findings highlight the importance of considering both IR and visceral adiposity in CVD risk assessments to improve the identification of high-risk individuals.
Study context
- Population
- Participants of the China Health and Retirement Longitudinal Study (CHARLS)CHARLS
- Participants
- 8,358 participants
- Exposure
- Combined triglyceride-glucose (TyG) index and Chinese Visceral Adiposity Index (CVAI) categories and cardiovascular disease (CVD) risk
- Outcome
- CVD (including CHD and stroke)
- Follow-up
- 9-year follow-up
Methodological detailsnationwide, 9-year follow-up, multiple imputation (multiple imputation by chained equations (MICE))
- Nationwide
- 9-year follow-up
- Multiple imputation (MICE)
Main finding
As reported in the abstract
CVD
Each group vs low TyG, low CVAIHazard ratio (95% CI)
Low TyG, high CVAIhighest CVD risk
1.87(1.57–2.24)
High TyG, high CVAI
1.75(1.49–2.06)
- Developed CVD
- 1,240 participants (14.8%)
- Coronary heart disease (CHD) cases
- 896
- Strokes
- 475
Observational data: associations, not effects.
Further findings
Subgroup and sensitivity analyses
- Consistent results across demographic groups and analytical conditions
Original publication
The interaction between triglyceride-glucose index and visceral adiposity in cardiovascular disease risk: findings from a nationwide Chinese cohort. Cardiovasc Diabetol. Published 27 November 2024. doi:10.
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