Resident memory CD8(+) T cells dominate lymphoid immune cell population in human pancreatic islets in health and type 2 diabetes
Authors' conclusion
In T2D islets, resident CD8(+) T cells with a central memory phenotype dominate the lymphoid immune cell population, similar to non-diabetic donors. These findings provide the first insights into the memory T cell composition in human pancreatic islets in T2D, suggesting that the diabetic condition does not significantly alter the lymphoid landscape of pancreatic islets.
Study context
- Population
- Dissociated pancreatic islets from organ donors with T2D and without diabetes
- Participants
- 13 vs 44
- Comparison
- T2D vs non-diabetic donor islets
- T2Dn = 13
- Non-diabeticn = 44reference
- Outcome
- Islet lymphoid immune cell composition
Methodological detailsmulticolor flow cytometry, human organ donors
- Multicolor flow cytometry
- Human organ donors
Main finding
As reported in the abstract
- In both T2D and non-diabetic islets, CD3(+) T cells were the predominant lymphocytes, mainly central and effector memory phenotypes, biased toward CD8(+) T cells expressing residency markers (CD69, CD103)
- CD19(+) B cells and CD3(-) CD16(+) CD56(+) natural killer (NK) cells were low in both groups
- Proportions of these immune cells and beta cells similar between T2D and non-diabetic donors
Further findings
- T2D donors had a higher proportion of glucagon-producing alpha cells and significantly reduced glucose-stimulated insulin secretion vs non-diabetic
Original publication
Resident memory CD8(+) T cells dominate lymphoid immune cell population in human pancreatic islets in health and type 2 diabetes. BMJ Open Diabetes Res Care. Published 11 March 2025. doi:10.
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