Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes
Authors' conclusion
Systematic human pancreatic analysis revealed two separate type 2 diabetes phenotypes: fatty, associated with central obesity; and fibrotic, associated with reduced beta cell mass without central obesity. This suggests distinct underlying pathogenic mechanisms and has potential for developing personalised disease-modifying therapeutics.
Study context
- Population
- Adult organ donor pancreases with/without type 2 diabetes
- Participants
- 36 donor pancreases
- Exposure
- Donors with vs without T2D
- Outcome
- Pancreatic adipocyte proportional area and fibrosis
Methodological detailsorgan donor pancreases, 16 anatomically defined regions, quantitative histology, transmission electron microscopy
- Organ donor pancreases
- 16 anatomically defined regions
- Quantitative histology
- Transmission electron microscopy
Main finding
As reported in the abstract
Adipocyte proportional area vs donor BMI (r)
r=0.385
p=0.021
Adipocyte proportional area vs acinar area (r)
r=−0.762
p<0.001
Adipocyte proportional area vs endocrine mass (r)
r=0.749
p<0.001
Pancreatic adipocytosis vs intra-acinar cell lipid content (inverse; lowest in T2D)
r=−0.490
p=0.003
Observational data: associations, not effects.
Original publication
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