Human Peripancreatic Adipose Tissue Paracrine Signaling Impacts Insulin Secretion, Blood Flow, and Gene Transcription
Authors' conclusion
The PAT secretome is metabolically negative compared to SAT, and impacts islet insulin secretion, blood flow, and gene transcription in a sex-dependent manner.
Study context
- Population
- Human donor adipose tissue obtained through the Human Pancreas Analysis Program
- Comparison
- Peripancreatic adipose tissue vs subcutaneous adipose tissue
- Outcome
- Paracrine signaling and effects of PAT secretome
Main finding
As reported in the abstract
- Greater secretion of interferon-γ and most inflammatory eicosanoids with peripancreatic adipose tissue (PAT) vs subcutaneous adipose tissue (SAT)
- Secretion of adipokines negatively related to metabolic health increased in PAT vs SAT
- No overall effect of PAT vs SAT on human islet insulin secretion; insulin secretion suppressed after PAT exposure from men vs women
- Vasodilation significantly dampened by PAT conditioned media, explained almost completely by PAT from men, not women
- Islets treated with PAT showed selective changes in lipid metabolism pathways; SAT altered cellular signaling and growth
- RNA sequencing: islet gene transcription changed by PAT vs SAT, biggest changes between PAT by sex
Original publication
Human Peripancreatic Adipose Tissue Paracrine Signaling Impacts Insulin Secretion, Blood Flow, and Gene Transcription. J Clin Endocrinol Metab. Published 1 November 2024. doi:10.
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