Lipids & metabolic liver disease
Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue
Authors' conclusion
Our findings uncover genetic determinants of human adipose tissue fatty acid composition, highlight depot-specific regulation, and point to SCD1 as a potential metabolic regulator. These results deepen understanding of lipid metabolism and its links to cardiometabolic risk.
Study context
- Population
- UK Biobank participants with MRI-derived estimates of fatty acid composition in SAT and visceral adipose tissue (VAT)UK Biobank
- Participants
- 33,583 participants
- Outcome
- Adipose tissue fatty acid composition in SAT and VAT
Methodological detailsMRI-derived fatty acid composition, fine mapping, colocalization, expression QTL analyses
- MRI-derived fatty acid composition
- Fine mapping
- Colocalization
- Expression QTL analyses
Main finding
As reported in the abstract
Loci associated with adipose tissue fatty acid composition
Loci identified
6
Shared loci (SAT and VAT)
PKD2L1, INSIG1
SAT-specific loci
LEKR1, KLF14
VAT-specific locus
CDCA2
Further findings
Cardiometabolic outcomes
- Several loci linked to T2D, hypertension and cholelithiasis; functional evidence supporting gene-diet interactions at the PKD2L1 locus
Original publication
Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue. Obesity (Silver Spring). Published 29 September 2025. doi:10.
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