Liver disease in people with latent autoimmune diabetes in adults (LADA): A cross-sectional study using magnetic resonance elastography
Authors' conclusion
Liver fat accumulates differently in LADA and in T1D compared to T2D, reflecting a different body fat distribution despite a similar BMI. Factors associated with liver stiffness differ among diabetes types.
Study context
- Population
- People with LADA, T2D and T1D; liver magnetic resonance (MR) and MR elastography for proton density fat fraction (PDFF) and stiffness; Visceral adipose tissue (VAT) by DXA
- Participants
- 31 / 31 / 31
- Exposure
- LADA vs T2D vs T1D
- LADAn = 31
- T2Dn = 31
- T1Dn = 31
- Outcome
- Liver steatosis (PDFF >5.5%)
Methodological detailsmatched
- Matched
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Liver stiffness
- Stiffness did not differ among groups
Factors associated with PDFF and liver stiffness
- Body mass index (BMI) a marker of liver fat content only in T2D (interaction p-value)
- <0.001
- BMI a marker of liver stiffness only in T2D (interaction p-value)
- 0.019
- HbA1c associated with liver stiffness differently among diabetes types (interaction p-value)
- 0.034
- VAT associated with liver stiffness differently among diabetes types (interaction p-value)
- 0.016
- VAT related to PDFF in whole population
- Kidney function inversely associated with liver stiffness in whole population, without differences by diabetes type
Original publication
Liver disease in people with latent autoimmune diabetes in adults (LADA): A cross-sectional study using magnetic resonance elastography. Diabetes Res Clin Pract. Published 8 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →