Optimal type and dose of exercise to improve glycated haemoglobin in individuals with type 1 diabetes: A systematic review and Bayesian dose–response network meta‐analysis of RCTs
Authors' conclusion
A dose of ME necessary to achieve MCID (e.g., 10 min of running and curl-ups, three times per week) was well below the American Diabetes Association's minimum recommendation. For adolescents, we recommend combining aerobic and resistance training, performed for at least 12 weeks with 160 to 1200 MET-min/week (equivalent to 25-220 min per week), to balance effectiveness and minimise exercise burden. The high-quality randomized controlled trials of this dose range are required to confirm efficacy and evaluate safety.
Study context
- Population
- Patients with T1D19 studies
- Comparison
- Exercise modes and doses vs control on HbA1c
- Outcome
- HbA1c
Methodological detailsrandom-effects model, no limits on date or language of publication
- Random-effects model
- No limits on date or language of publication
Pooled result
As reported in the abstract
ME significantly reduced HbA1c
−0.81%
95% CrI −1.33 to −0.34; SUCRA 93.75%; low-quality evidence
High-intensity interval training, no significant benefit
−0.38%
95% CrI −1.16 to 0.39; SUCRA 51.52%
Aerobic exercise, no significant benefit
−0.31%
95% CrI −0.74 to 0.16; SUCRA 47.01%
Further pooled results
ME dose–response (L-shaped, non-linear)
- Statistical significance reached at (MET-min/week)
- 52
- Minimal clinically important difference (MCID) (≥ 0.5% reduction) achieved at 160 MET-min/week
- −0.52% (95% CrI −0.89 to −0.13)
- Greatest reduction at 1500 MET-min/week
- −0.82% (95% CrI −1.31 to −0.27)
Original publication
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