Nonpharmacological interventions on glycated haemoglobin in youth with type 1 diabetes: a Bayesian network meta-analysis
Authors' conclusion
The current study underscores non-pharmacological options such as multicomponent exercise and nutritional supplements, showcasing their potential to significantly improve HbA1c in youth with type 1 diabetes.
Study context
- Population
- Children and adolescents with T1D; Randomised clinical trials (RCTs) of nonpharmacological interventions (e.g., physical activity, nutrition, behavioural therapies); PubMed, Web of Science, Scopus, SPORTDiscus to July 1, 2023
- Participants
- 6,815 children74 RCTs
- Comparison
- Nonpharmacological interventions vs standard care
- Multicomponent exercisen = 214
- Nutritional supplementsn = 146
- Outcome
- Change in HbA1c
Pooled result
As reported in the abstract
SMD
- 0.63
95% CrI - 1.09 to - 0.16
Multicomponent exercise
SMD
- 0.49
95% CrI - 0 .92 to - 0.07
Nutritional supplements
Further pooled results
| Outcome | SMD (95% CrI) |
|---|---|
| Change in daily insulin dose requirementMulticomponent exercise vs Standard care · n = 119 · CrI | - 0.79 (- 1.19 to - 0.34) |
| Change in daily insulin dose requirementNutritional supplements vs Standard care · n = 57 · CrI | - 0.62 (- 1.18 to - 0.12) |
Original publication
Nonpharmacological interventions on glycated haemoglobin in youth with type 1 diabetes: a Bayesian network meta-analysis. Cardiovasc Diabetol. Published 1 July 2024. doi:10.
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