TLR5 influences the development of type 1 diabetes
Authors' conclusion
In the present study, we find a low expression of mRNA for TLR5 in patients with newly diagnosed T1D associated with enhanced T cell infiltration. T cells are important for autoimmune diseases, including T1D. We hope that the present findings may be influential for the understanding of how T1D develops.
Study context
- Population
- Patients with newly diagnosed T1D (islets of Langerhans mRNA) and female diabetic non-obese diabetic (NOD) mice (whole pancreatic tissue)
- Comparison
- Newly diagnosed T1D vs controls
- Outcome
- Islet TLR5 mRNA
Main finding
As reported in the abstract
- Islet mRNA for TLR5 downregulated by one-third in newly diagnosed T1D vs controls
- Islet TLR5 mRNA correlated inversely with T cell infiltration in the islets
- Tlr5 and Cd3 expression correlated correspondingly in pancreatic tissue of diabetic NOD mice
Further findings
- Two associations found between TLR5 and monocytes
- A significant polymorphism seen concerning TLR5 and T1D
Original publication
TLR5 influences the development of type 1 diabetes. BMJ Open Diabetes Res Care. Published 5 September 2025. doi:10.
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