Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes
Authors' conclusion
This was the largest coordinated effort to examine the presence of enterovirus RNA in the pancreas of organ donors with type 1 diabetes, using a multitude of assays. These findings are consistent with the notion that donors with type 1 diabetes and donors with islet autoantibodies may carry a low-grade enterovirus infection in the pancreas and lymphoid tissues.
Study context
- Population
- Organ donors with and without T1D (nPOD); pancreas, spleen, pancreatic lymph nodes and duodenum samples
- Participants
- 71 / 22 / 74
- Exposure
- Enterovirus RNA detection in donors with T1D vs islet autoantibody-positive vs control donors
- T1Dn = 71
- Autoantibody-positiven = 22
- Controln = 74reference
- Outcome
- Presence of enterovirus RNA in pancreas and lymphoid tissues
Methodological detailsmulticentre (five research laboratories), organ donor tissue study
- Multicentre (five research laboratories)
- Organ donor tissue study
Main finding
As reported in the abstract
Enterovirus RNA detected by RT-PCR in pancreas
Single autoantibody-positive vs T1D with insulin-deficient islets: P < 0.001 · Single autoantibody-positive vs Control: P = 0.004
Observational data: associations, not effects.
Further findings
Enterovirus RNA in lymphoid tissues
- Pancreatic lymph nodes also positive in some donors
- RT-PCR detected enterovirus RNA in spleen of a small number of donors; virus enrichment in cell lines gave much higher spleen positivity, particularly in T1D
- Detected strains did not cause typical lytic infection
Original publication
Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. Diabetologia. Published 17 March 2025. doi:10.
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