Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk
Authors' conclusion
Using an organ-based model system of inflammatory stress, we validated a signature of EV-associated miRNAs capable of stratifying type 1 diabetes risk.
Study context
- Population
- Human islets exposed to IL-1β+IFN-γ; plasma extracellular vesicles (EVs) from individuals with AAb+ or recent-onset T1D and matched controls; pancreatic sections from organ donors; NOD mice
- Outcome
- Inflammation-induced miRNA program in islets, islet-derived EVs and plasma EVs
Methodological detailshuman islet model of inflammatory stress, plasma EV biomarker validation with localised surface plasmon resonance (LSPR) biosensors, pancreatic sections from organ donors, NOD mouse model
- Human islet model of inflammatory stress
- Plasma EV biomarker validation with LSPR biosensors
- Pancreatic sections from organ donors
- NOD mouse model
Main finding
As reported in the abstract
Differentially expressed microRNA (miRNAs) in islets after cytokine exposure
20
Differentially expressed miRNAs in islet-derived EVs
14
miR-155-5p and miR-146a-5p concordantly upregulated in both compartments
2
Original publication
Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk. Diabetologia. Published 21 April 2026. doi:10.
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