Islet Autoantibodies in Adult With Pituitary and Ovarian Autoimmunity: Implications for Type 1 Diabetes Screening
Authors' conclusion
Adults with specific autoimmunity disorders, particularly those affecting ovarian and/or pituitary glands, have a higher prevalence of pancreatic autoimmunity.
Study context
- Population
- Adults previously tested for autoantibodies against specific endocrine glands and/or gastric parietal cells by indirect immunofluorescence
- Exposure
- Adults with organ-specific autoimmunity vs controls without
- Outcome
- Prevalence of pancreatic autoimmunity (positivity for at least one islet-AAb)
Methodological detailsre-evaluation of stored serum samples
- Re-evaluation of stored serum samples
Main finding
As reported in the abstract
Positivity for at least one islet-AAb
P = 0.007
Observational data: associations, not effects.
Further findings
Double and triple islet-AAb positivity
- Less common overall, but more frequent in Group A
Multiple positivity (≥ 2 islet-AAb) within Group A by pattern of autoimmunity
- Significantly higher prevalence in subjects with ovarian autoimmunity and with combined pituitary and ovarian autoimmunity than in those with other endocrine autoimmune involvement
Original publication
Islet Autoantibodies in Adult With Pituitary and Ovarian Autoimmunity: Implications for Type 1 Diabetes Screening. Diabetes Obes Metab. Published 20 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →