Islet autoimmunity and progression to type 1 diabetes in the Finnish Diabetes Prediction and Prevention (DIPP) study: comparison between genetically susceptible children with and without an affected first-degree relative
Authors' conclusion
At seroconversion, genetically susceptible children who had one or more FDRs with type 1 diabetes, especially an affected father, were more often positive for GADA and multiple islet autoantibodies. During the follow-up period, children with an affected FDR were more often positive for IAA, GADA and IA-2A, and progressed to clinical type 1 diabetes more often and faster than children without an affected FDR. These data should be considered when designing intervention and screening studies.
Study context
- Population
- Children with HLA-conferred susceptibility followed from birth (Finnish DIPP study) with confirmed positivity for at least one islet autoantibodyislet autoantibody positive
- Participants
- 1,334 children
- Exposure
- Children with vs without an affected first-degree relative with T1D
- First-degree relative (FDR)+n = 145
- FDRs (FDR-) FDR+n = 87
- Outcome
- Progression to clinical diabetes
- Follow-up
- Median 8.6 years
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Seroconversion age
Years
| Outcome | FDR+ | FDR- FDR+ | FDR- |
|---|---|---|---|
| Time from seroconversion to clinical diabetes | 2.7 | — not stated in the abstract | 3.6 |
— not stated in the abstract
- Multiple autoantibodies at seroconversion, subgroup: paternal vs maternal T1D at birth: Paternal T1D (n=71) 39.4%
- Multiple autoantibodies at seroconversion, subgroup: paternal vs maternal T1D at birth: Maternal T1D (n=50) 20.0%
Seroconversion age
- Seroconversion age similar between the three groups
GADA and multiple autoantibodies at seroconversion
- FDR+ and FDR- FDR+ significantly more often positive for GADA and multiple autoantibodies than FDR-
Autoantibodies during follow-up
- FDR+ and FDR- FDR+ more often had IAA, GADA, IA-2A and multiple autoantibodies than FDR-
Time from seroconversion to clinical diabetes
- Significantly shorter in FDR+ vs FDR-
Multiple autoantibodies at seroconversion, subgroup: paternal vs maternal T1D at birth
- Paternal T1D twice as often positive for multiple autoantibodies as maternal T1D
Original publication
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