Liver fat content is not elevated in people with type 1 diabetes: the Maastricht Study
Authors' conclusion
The liver fat content of individuals with type 1 diabetes was comparable to that of people without diabetes and lower than that in those with type 2 diabetes. This difference was independent of the level of obesity, dietary factors and other potential confounders, but was partially explained by insulin sensitivity and insulin treatment.
Study context
- Population
- Participants of The Maastricht Study with T1D, T2D or normal glucose metabolism, matched on BMI, sex, age and educational level1:2:2 matched
- Participants
- 29 / 58 / 58
- Exposure
- Liver fat content in T1D vs T2D vs normal glucose metabolism
- T1Dn = 29
- T2Dn = 58
- Normal glucose metabolismn = 58reference
- Outcome
- Liver fat content estimated by MRI (log-transformed)
Methodological detailsThe Maastricht Study, 1:2:2 matching on BMI, sex, age and educational level, multiple linear regression, MRI-estimated liver fat
- The Maastricht Study
- 1:2:2 matching on BMI, sex, age and educational level
- Multiple linear regression
- MRI-estimated liver fat
Main finding
As reported in the abstract
Liver fat content
T1D vs T2D: P = 0.001 · T1D vs Normal glucose metabolism: P = 0.064
Observational data: associations, not effects.
Original publication
Liver fat content is not elevated in people with type 1 diabetes: the Maastricht Study. Diabetologia. Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →