Comparing Automated Lyumjev® Delivery with Carbohydrate Counting, Qualitative Meal-Size Estimation, and Fully Closed-Loop in Type 1 Diabetes: A Pilot, Randomized, Crossover Trial
Authors' conclusion
In this pilot study, the AID system using Lyumjev simplified or alleviated carbohydrate counting without degrading glucose control more than 5%. Larger studies are warranted.
Study context
- Population
- Adults with T1D; 8 females; mean age 38 (SD 16) years, HbA1c 7.0% (SD 0.7), total daily insulin dose 0.64 (SD 0.22) U/(kg·d)12 completed
- Comparison
- Automated insulin delivery (AID) with qualitative meal-size estimation and AID with meal detection (fully closed-loop) vs AID with carbohydrate counting, using ultrarapid lispro (Lyumjev)
Methodological detailspilot
- Pilot
Primary result
As reported in the abstract
Overall TIR · 3 weeks per intervention
AID-estimate vs AID-count: P = 0.191 · AID-fully vs AID-count: P = 0.192
Further findings
Time in hyperglycaemia
- Differences not statistically significant
Time in hypoglycaemia
- Low and not different between interventions
Safety
- Episodes of severe hypoglycaemia or DKA in any intervention
- 0
Original publication
Comparing Automated Lyumjev® Delivery with Carbohydrate Counting, Qualitative Meal-Size Estimation, and Fully Closed-Loop in Type 1 Diabetes: A Pilot, Randomized, Crossover Trial. Diabetes Technol Ther. Published 10 June 2026. doi:10.
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