Abnormal Glycaemic Fluctuations Associated With Early Microvascular Changes in the Retina and Choroid of Nondiabetic Adults
Authors' conclusion
Increased glycaemic variability even in nondiabetic adults is associated with reduced blood flow density and decreased choroidal thickness.
Study context
- Population
- Community-based nondiabetic adults (oral glucose tolerance tests (OGTT)-confirmed) at high risk for T2D, assessed with OGTT, continuous glucose monitoring (CGM) and optical coherence tomography angiography (OCTA)OGTT-confirmed nondiabetic
- Participants
- 338 adults
- Exposure
- Abnormal glucose fluctuation (AGF) vs normal glucose fluctuation (NGF), categorized by mean amplitude of glycaemic excursions (MAGE)
- AGFn = 73
- NGFn = 265reference
- Outcome
- Retinal and choroidal microvascular measures, AGF vs NGF
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
- Choroidal large-vessel volume area ratio (CVV/a) reduced in AGF
- Choroidal vascular index (CVI) increased in AGF
- Choroidal thickness decreased in AGF
- AGF vs NGF: P = 0.007
- AGF vs NGF: P = 0.003
- AGF vs NGF: P = 0.014
- AGF vs NGF: P = 0.005
Observational data: associations, not effects.
Further findings
Correlation of CGM metrics with blood flow density (multiple linear regression)
- MAGE and coefficient of variation (CV) negatively correlated with retinal and choroidal blood flow density
Original publication
Abnormal Glycaemic Fluctuations Associated With Early Microvascular Changes in the Retina and Choroid of Nondiabetic Adults. Diabetes Obes Metab. Published 10 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →