β-Cell Dysfunction Identifies Individuals With Single Autoantibody Positivity at Increased Risk of Type 1 Diabetes Progression
Authors' conclusion
β-Cell dysfunction is present in many individuals with single autoantibody positivity and is associated with an increased risk of disease progression.
Study context
- Population
- First- and second-degree relatives of persons with T1D confirmed positive for a single islet autoantibody, TrialNet Pathway to Prevention Natural History study
- Outcome
- Time to progression: development of multiple autoantibody-positive or stage 3 T1D
Methodological detailsCox proportional hazards models, random forest models, stratified by age (0-8, ≥8-16, ≥16 years)
- Cox proportional hazards models
- Random forest models
- Stratified by age (0-8, ≥8-16, ≥16 years)
Main finding
As reported in the abstract
Association of metabolic measures with progression
Data-driven cutoffs for combined metabolic measures identified small very-high-risk subsets
>50% 2-year progression
Data-driven cutoffs identified large low-risk groups
<10% 5-year progression
Observational data: associations, not effects.
Original publication
β-Cell Dysfunction Identifies Individuals With Single Autoantibody Positivity at Increased Risk of Type 1 Diabetes Progression. Diabetes Care. Published 2 September 2026. doi:10.
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