Extremely Early Appearance of Islet Autoantibodies in Genetically Susceptible Children
Authors' conclusion
Islet autoimmunity by the age of 0.50 years was rare in genetically susceptible children and was typically initiated with IAA. Confirmed positivity was less common in children with autoantibodies at age ≤0.50 than at slightly older age. The secular decrease of islet autoimmunity before age 0.50 years was observed. This trial is
Study context
- Population
- Finnish children with increased HLA-conferred risk for T1D in the Diabetes Prediction and Prevention (DIPP) or the Environmental Determinants of Diabetes in the Young (TEDDY) study; maternally transferred antibodies excluded
- Participants
- 20,979 children
- Exposure
- Islet autoantibodies at ≤0.50 years vs 0.51-0.75 years; four birth cohorts 1994-2019
- ≤0.50 yearsn = 53
- Outcome
- At least one islet autoantibody at age ≤0.50 years
Methodological detailsDIPP and TEDDY cohorts, HLA-conferred risk
- DIPP and TEDDY cohorts
- HLA-conferred risk
Main finding
As reported in the abstract
≤0.50 years
0.25%
53
Observational data: associations, not effects.
Further findings
Confirmed positivity during follow-up · more common in the older group
P = 0.002
Outcomes of children with autoantibodies at ≤0.50 years · mean follow-up 8.1 years
- Progressed to T1D
- 15.1%
- Median age at T1D diagnosis
- 2.0 years
- Confirmed islet autoimmunity but no T1D
- 43.4%
- Only transient islet autoantibodies
- 41.5%
Age at T1D diagnosis among progressors by first autoantibody
- IAA-initiated autoimmunity
- 1.0-2.4 years
- ZnT8A-initiated autoimmunity
- 4.5-16.1 years
Appearance of islet autoantibodies at ≤0.50 years across four birth cohorts 1994-2019
- Decreased towards the most recent birth cohorts
- P = 0.016
Original publication
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