Long-term Risk for Type 1 Diabetes and Obesity in Early Term Born Offspring: A Systematic Review and Meta-Analysis
Pooled result · T1DResult — go to the resultRelative risk 1.19 CI 1.13–1.25Authors' conclusion
Compared with full-term offspring, early-term delivery poses a modest risk for long-term pediatric type 1 diabetes. Our analysis supports that, whenever medically possible, elective delivery should be avoided before 39 completed weeks of gestation.
Study context
- Population
- Offspring up to the age of 18 years; observational cohort studies from PubMed, Medline and EMBASE11 studies
- Comparison
- Early-term vs full-term delivery
- Outcome
- Long-term risk for T1D and obesity
- Follow-up
- Up to age 18 years
Methodological detailstwo independent reviewers, funnel plots with Egger's regression, sensitivity analyses, All studies scored high quality (Newcastle-Ottawa Scale), Most studies adjusted for at least some confounders
- Two independent reviewers
- Funnel plots with Egger's regression
- Sensitivity analyses
- All studies scored high quality (Newcastle-Ottawa Scale)
- Most studies adjusted for at least some confounders
Pooled result
T1D
Relative risk
1.19
CI 1.13–1.25
Early-termvs Full-term
RR 1.19 (CI 1.13–1.25)
As reported in the abstract
Further pooled results
| Outcome | RR (CI) | |
|---|---|---|
| Overweight and obesityWeaker association | 1.05 (0.97–1.12) | |
| 0.512Relative risk (log scale) |
Original publication
Long-term Risk for Type 1 Diabetes and Obesity in Early Term Born Offspring: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. Published 11 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →