Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes
Authors' conclusion
Elevated ARO in SAT was found in obese men, and this was linked to insulin resistance and glycemia, supporting the idea that local estrogen production contributes to metabolic dysregulation. ESR1 was reduced in men with T2D and was linked to adiposity and insulin resistance. Taken together, high ARO and altered ESR1:ESR2 balance in SAT in obese men may contribute to insulin resistance and T2D development.
Study context
- Population
- Men with or without obesity or T2D; subcutaneous adipose tissue (SAT)
- Comparison
- Men with obesity or T2D vs men without
- Outcome
- ARO, ESR1 and ESR2 expression in SAT
Methodological detailsex vivo glucose uptake measurements
- Ex vivo glucose uptake measurements
Main finding
As reported in the abstract
- Aromatase (ARO) levels higher in SAT from men with obesity vs nonobese men
- ARO gene expression correlated positively with adiposity, hyperglycemia and insulin resistance
- No association between ARO and circulating E2
- Men with obesity had lower ESR1 and ESR1:ESR2 ratio, but not ESR2
- ESR1 gene expression correlated negatively with adiposity, insulin resistance markers and ARO expression; tended to be lower in men with T2D
- E2 reduced insulin-stimulated glucose uptake; testosterone increased basal glucose uptake in adipocytes
Original publication
Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes. J Clin Endocrinol Metab. Published 21 January 2025. doi:10.
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