Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures
Authors' conclusion
Decreased adipose tissue expression of genes involved in browning and adiponectin with increased environmental temperatures were observed. Given the North-South gradient of obesity prevalence in these same regions, the present observations could have implications for the relationship of the obesity pandemic with global warming.
Study context
- Population
- Individuals with subcutaneous adipose tissue (SAT) samples recruited in 5 regions of Spain (3 North, 2 South)
- Participants
- 1,083 individuals
- Outcome
- SAT gene expression and adiponectin vs environmental temperature
Methodological detailsmulticentre (5 regions of Spain), univariate, multivariate and artificial intelligence (Boruta algorithm) analyses, Gene expression by quantitative PCR; adiponectin by ELISA; temperatures from the National Agency of Meteorology
- Multicentre (5 regions of Spain)
- Univariate, multivariate and artificial intelligence (Boruta algorithm) analyses
- Gene expression by quantitative PCR; adiponectin by ELISA; temperatures from the National Agency of Meteorology
Main finding
As reported in the abstract
- SAT expression of browning genes (UCP1, PRDM16, CIDEA) and ADIPOQ significantly negatively associated with minimum, average and maximum temperatures
- Temperatures also negatively associated with expression of adipogenesis genes (FASN, SLC2A4, PLIN1)
- Decreased SAT UCP1 and ADIPOQ mRNA and circulating adiponectin with increasing temperatures in all individuals and in those with obesity, in univariate, multivariate and artificial intelligence analyses
Observational data: associations, not effects.
Further findings
Subgroups: without T2D; samples collected in winter
- Differences remained statistically significant in individuals without T2D and in samples collected during winter
Original publication
Downregulated Adipose Tissue Expression of Browning Genes With Increased Environmental Temperatures. J Clin Endocrinol Metab. Published 10 August 2023. doi:10.
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