Association of early post‐transplant hyperglycaemia and diabetes mellitus on outcomes following heart transplantation
Authors' conclusion
EPTH and PTDM are highly prevalent following cardiac transplantation. EPTH develops within days of transplant and is strongly associated with progression to PTDM. Pre-existing T2DM, PTDM and EPTH are associated with greater hospitalization, increased episodes of rejection and worse 5-year survival compared to patients who remained free from diabetes during follow-up.
Study context
- Population
- Heart transplant recipients followed for 5 years, single centre in Sydney, Australia
- Participants
- 141 recipients
- Exposure
- Early post-transplant hyperglycaemia (EPTH), post-transplant diabetes mellitus (PTDM) and pre-existing T2D vs remaining free from diabetes
- Pre-existing T2Dn = 25
- Free from diabetes at baselinen = 116
- Outcome
- Prevalence of EPTH and cumulative prevalence of PTDM in recipients free from diabetes at baseline
- Follow-up
- 5 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
EPTH
88 of 116
76%
PTDM, all of whom had experienced EPTH
45 of 116
39%
Observational data: associations, not effects.
Further findings
Outcomes with EPTH
- EPTH associated with higher rates of acute rejection and hospitalizations, and lower 5-year survival
Outcomes with PTDM and pre-existing T2D vs remaining free from diabetes
- Both PTDM and pre-existing T2D associated with increased rates of graft rejection and hospitalization, and greater than three-fold increased likelihood of death
Original publication
Association of early post‐transplant hyperglycaemia and diabetes mellitus on outcomes following heart transplantation. Diabet Med. Published 25 September 2024. doi:10.
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