Lipids & metabolic liver disease
Derivatives of the triglyceride–glucose index and their association with incident hypertension in prehypertensive individuals: a 4-year cohort study augmented by mendelian randomization
Authors' conclusion
Our study reveals a significant link between the TyG index and its related indicators with new-onset hypertension in prehypertensive populations. Causal analysis using BWMR confirmed that genetically elevated TyG index levels increase the risk of new-onset hypertension. These results highlight the importance of monitoring TyG-related indices for early detection and intervention in high-risk individuals, aiding in the prevention of hypertension progression.
Study context
- Population
- Prehypertensive participants from the 2011 CHARLS database877 progressed to hypertension
- Participants
- 2,815 participants
- Exposure
- TyG index and derived metrics, per unit and by quartiles
- Outcome
- New-onset hypertension
- Follow-up
- By 2015
Methodological details4-year follow-up, Bayesian weighted MR
- 4-year follow-up
- Bayesian weighted MR
Main finding
As reported in the abstract
Per unit increase, as printed
- Incidence of new-onset hypertension
- 877 (31.15%)
- Higher quartiles (Q3 and Q4) of TyG and derived metrics significantly linked to elevated risk across all models
- P < 0.001
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline (RCS))
- TyG index and TyG-Waist Circumference (TyG-WC): significant positive linear relationships (P for overall < 0.001)
- P for nonlinearity = 0.844 and 0.165, respectively
- TyG-Waist-to-Height Ratio (TyG-WHtR) and TyG-Body Mass Index (TyG-BMI): significant positive nonlinear relationships (P for overall < 0.001)
- P for nonlinearity = 0.001 and 0.046, respectively
Subgroup analyses
- Stronger associations in those aged ≥ 70 years, widowed, with CVD, or life satisfaction score of 2
- P < 0.05, P for interaction < 0.05
Bayesian weighted MR (BWMR) causal analysis
- Significant causal relationship between genetically elevated TyG index and increased risk of new-onset hypertension
- P < 0.05
Original publication
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