Lipids & metabolic liver disease
Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans
Authors' conclusion
These findings define a distinct lipidomic signature of acute cold exposure in humans and suggest that even short-term BAT activation is associated with coordinated remodelling of circulating lipid networks.
Study context
- Population
- Young sedentary adults (72% women)
- Participants
- 58 adults
- Comparison
- Before vs during 2-h cold exposure
- Outcome
- Plasma lipidome (656 lipid species, 14 subclasses) during acute cold exposure
- Follow-up
- 2-h cold exposure
Methodological detailsMass spectrometry-based lipidomics; associations with brown adipose tissue (BAT) volume, activity and mean radiodensity assessed
- Mass spectrometry-based lipidomics; associations with BAT volume, activity and mean radiodensity assessed
Main finding
As reported in the abstract
- Acute cold exposure increased circulating membrane-associated phospholipids
- Acute cold exposure decreased triacylglycerol (TG) and phosphatidylethanolamine (PE) species
- Largest shifts in phospholipids and TG among species with shorter and less unsaturated acyl chains
- Cold-induced reductions in circulating TG species negatively correlated with BAT mean radiodensity
Original publication
Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans. Diabetes Obes Metab. Published 20 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →