Lipids & metabolic liver disease
Fetuin B Is Related to Cytokine/Chemokine and Insulin Signaling in Adipose Tissue and Plasma in Humans
Authors' conclusion
Plasma fetuin B is related to adipose tissue genes and plasma proteins involved in metabolic processes and insulin signaling. Our findings provide evidence for the involvement of white adipose tissue in fetuin B-induced insulin resistance.
Study context
- Population
- Humans in a large cohort; adipose tissue transcriptome and plasma proteomeadipose tissue transcriptome 207 · plasma proteome 558
- Outcome
- Association of plasma fetuin B with the adipose tissue transcriptome and plasma proteome
Methodological detailstranslational, multicentre
- Translational
- Multicentre
Main finding
As reported in the abstract
Plasma fetuin B associations (continuous linear regression; model 1: sex, age, study center; model 2: + BMI; model 3: + Matsuda index)
White adipose tissue genes associated with plasma fetuin B
more than 100 genes
Plasma proteins associated with plasma fetuin B, in metabolic process and insulin signaling pathways (all models)
more than 146 plasma proteins
Observational data: associations, not effects.
Original publication
Fetuin B Is Related to Cytokine/Chemokine and Insulin Signaling in Adipose Tissue and Plasma in Humans. J Clin Endocrinol Metab. Published 7 February 2025. doi:10.
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