Lipids & metabolic liver disease
Comparative Predictive Value of Three Visceral Adiposity Indices for Cardiovascular Disease: A 17.5‐Year Korean Cohort Study
Authors' conclusion
METS-VF, VAI, and LAP were independently associated with an increased risk of CVD events. Among these indices, METS-VF demonstrated relatively better discriminatory performance
Study context
- Population
- Middle-aged Korean adults without cardiovascular diseases (CVD) at baseline, Korean Genome and Epidemiology Study
- Participants
- 8,192 adults
- Exposure
- Highest vs lowest tertile of metabolic score for visceral fat (METS-VF), visceral adiposity index (VAI) and lipid accumulation product (LAP)
- Outcome
- Incident CVD (self-reported physician diagnoses confirmed by trained interviewers)
Methodological detailscommunity-based cohort (Korean Genome and Epidemiology Study), multivariable Cox proportional hazard regression
- Community-based cohort (Korean Genome and Epidemiology Study)
- Multivariable Cox proportional hazard regression
Main finding
As reported in the abstract
Incident CVD
Adjusted hazard ratio (95% CI)
METS-VF highest tertilevs METS-VF lowest tertile
1.62(1.29–2.03)
VAI highest tertilevs VAI lowest tertile
1.38(1.08–1.77)
LAP highest tertilevs LAP lowest tertile
1.66(1.32–2.09)
Observational data: associations, not effects.
Further findings
Discriminatory performance for incident CVD (Heagerty's iAUC)
- METS-VF showed statistically higher discriminatory performance than VAI and LAP (p < 0.001); overall discriminative ability of indices was modest
Original publication
Comparative Predictive Value of Three Visceral Adiposity Indices for Cardiovascular Disease: A 17.5‐Year Korean Cohort Study. Diabetes Obes Metab. Published 15 April 2026. doi:10.
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