Lipids & metabolic liver disease
Association of triglyceride glucose-related parameters with all-cause mortality and cardiovascular disease in non-alcoholic fatty liver disease (NAFLD) patients: National Health and Nutrition Examination Survey (NHANES) 1999–2018
Authors' conclusion
The predictive value of TyG or TyG-WHtR for all-cause mortality and cardiovascular risk in NAFLD patients was significant. The TyG index and TyG-WHtR might be valid predictors of cardiovascular outcomes of patients with NAFLD.
Study context
- Population
- Adults aged ≥18 years with NAFLD, NHANES 1999–2018
- Participants
- 6,627 adults
- Exposure
- Triglyceride-glucose (TyG) index vs triglyceride glucose-waist height ratio (TyG-WHtR) as predictors of mortality and CVD
- Outcome
- Associations with all-cause mortality, CVD mortality and cardiovascular diseases (CVDs)
Methodological detailsweighted logistic regression, Cox proportional hazards model, restricted cubic spline, mediation analysis
- Weighted logistic regression
- Cox proportional hazards model
- Restricted cubic spline
- Mediation analysis
Main finding
As reported in the abstract
| Group | All-cause mortality HR (95% CI) | CVD mortality HR (95% CI) | Chronic heart failure (CHF) OR (95% CI) | Total-CVD OR (95% CI) | Coronary heart disease (CHD) OR (95% CI) | Angina pectoris OR (95% CI) |
|---|---|---|---|---|---|---|
| TyG-WHtR | 1.31 (1.03-1.66) | 2.22 (1.42-3.47) | 3.99 (1.79-8.93) | |||
| TyG | 2.00 (1.26-3.18) | 1.85 (1.19-2.91) | 2.93 (1.23-7.00) |
All-cause mortality HR (95% CI)
TyG-WHtR1.31 (1.03-1.66)
TyG— not stated in the abstract
CVD mortality HR (95% CI)
TyG-WHtR2.22 (1.42-3.47)
TyG— not stated in the abstract
Chronic heart failure (CHF) OR (95% CI)
TyG-WHtR3.99 (1.79-8.93)
TyG— not stated in the abstract
Total-CVD OR (95% CI)
TyG-WHtR— not stated in the abstract
TyG2.00 (1.26-3.18)
Coronary heart disease (CHD) OR (95% CI)
TyG-WHtR— not stated in the abstract
TyG1.85 (1.19-2.91)
Angina pectoris OR (95% CI)
TyG-WHtR— not stated in the abstract
TyG2.93 (1.23-7.00)
Observational data: associations, not effects.
Further findings
Dose-response shape (restricted cubic spline (RCS), adjusted)
- Most relationships linear
- P overall < 0.0001, P-nonlinear > 0.05
- TyG and TyG-WHtR with all-cause mortality and CHF non-linear
- P overall < 0.0001, P nonlinear < 0.05
Incremental predictive value
- Adding TyG and TyG-WHtR to basic model improved C-statistics, NRI and IDI
Original publication
Association of triglyceride glucose-related parameters with all-cause mortality and cardiovascular disease in NAFLD patients: NHANES 1999–2018. Cardiovasc Diabetol. Published 18 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →