Lipids & metabolic liver disease
Association of triglyceride-glucose related indices with mortality among individuals with MASLD combined with prediabetes or diabetes
Authors' conclusion
Elevated levels of TyG, TyG-BMI, TyG-WHtR, TyG-WWI, and TyG-WC indices were associated with a poorer prognosis in MASLD patients with prediabetes or diabetes, with TyG-WWI being the strongest predictor.
Study context
- Population
- Patients with MASLD combined with prediabetes or DM, NHANES III
- Exposure
- Triglyceride-glucose (TyG)-related indices and mortality
- Outcome
- All-cause and cardiovascular/diabetes-specific mortality
- Follow-up
- Median 25.4 years
Methodological detailsNHANES III, Cox regression, restricted cubic spline analysis, time-dependent AUC
- NHANES III
- Cox regression
- Restricted cubic spline analysis
- Time-dependent AUC
Main finding
As reported in the abstract
Deaths
1,163
53.9%
Cardiovascular deaths
329
15.3%
Diabetes deaths
78
3.6%
Observational data: associations, not effects.
Further findings
MASLD prevalence among patients with prediabetes or DM
- Diagnosed with MASLD
- 46.5%
Dose-response (restricted cubic spline (RCS)) with all-cause mortality
- Positive linear relationship, TyG and TyG-WWI (p for nonlinear = 0.920; p = 0.525, respectively)
- Positive nonlinear association, TyG-waist circumference (TyG-WC), TyG-body mass index (TyG-BMI) and TyG-waist-to-height ratio (TyG-WHtR) (p for nonlinear = 0.001; = 0.003; = 0.007, respectively)
Predictive ability (time-dependent AUC)
- TyG-WWI the most robust predictor of both all-cause and cardiovascular mortality
Original publication
Association of triglyceride-glucose related indices with mortality among individuals with MASLD combined with prediabetes or diabetes. Cardiovasc Diabetol. Published 1 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →