Lipids & metabolic liver disease
Inflammation, nutrition, and biological aging: The prognostic role of Naples prognostic score in nonalcoholic fatty liver disease outcomes
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.26 95 % CI 1.19–1.34Authors' conclusion
This study found that NPS has the potential to be an independent, cost-effective, and reliable novel prognostic indicator for NAFLD that may complement existing tools and help improve risk stratification and management strategies for NAFLD, thereby preventing adverse outcomes.
Study context
- Population
- Nonalcoholic fatty liver disease (NAFLD) patients in the 1999–2018 National Health and Nutrition Examination Survey (NHANES)
- Participants
- 10,035 patients
- Exposure
- Naples Prognostic Score (NPS) vs FIB-4 and NAFLD fibrosis score (NFS) for predicting mortality
- Outcome
- All-cause mortality
Main finding
As reported in the abstract
Hazard ratio
1.26
95 % CI 1.19–1.34
NPS
HR 1.26 (95 % CI 1.19–1.34)
Per point increase in NPS, as printed
- Increased risk of all-cause mortality per point increase in NPS
- 26 %
Observational data: associations, not effects.
Further findings
Predictive performance vs FIB-4 and NFS
- HR, NPS + FIB-4
- 2.03
- HR, NPS + NFS
- 2.11
- NPS comparable predictive performance to FIB-4 and NFS
Mediation by PhenoAgeAccel
- Proportion of NPS effect on mortality mediated by PhenoAgeAccel
- 31.5 %
Original publication
Inflammation, nutrition, and biological aging: The prognostic role of Naples prognostic score in nonalcoholic fatty liver disease outcomes. Diabetes Res Clin Pract. Published 19 June 2024. doi:10.
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