Lipids & metabolic liver disease
Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort
Authors' conclusion
Both the TyG index and its related parameters were significantly and positively associated with ASCVD. TyG-WC and TyG-WHtR had better performance in predicting incident ASCVD than TyG, which might be more suitable indices for risk stratification and enhance the primary prevention of ASCVD.
Study context
- Population
- Atherosclerotic cardiovascular disease (ASCVD)-free participants of the Kailuan study8,031 ASCVD cases
- Participants
- 95,342 participants
- Exposure
- Triglyceride glucose (TyG) index and related parameters and incident ASCVD
- Outcome
- Incident ASCVD (MI and ischemic stroke)
- Follow-up
- Median 15.0 years
Methodological detailsKailuan study
- Kailuan study
Main finding
As reported in the abstract
Incident ASCVD per 1 IQR increase of baseline index
| Group | HR per 1 IQR |
|---|---|
| TyG | 1.39 (95% CI 1.35, 1.43) |
| TyG-BMI | 1.46 (95% CI 1.41, 1.50) |
| TyG-WC | 1.50 (95% CI 1.46, 1.55) |
| TyG-WHtR | 1.52 (95% CI 1.48, 1.57) |
HR per 1 IQR
TyG1.39 (95% CI 1.35, 1.43)
TyG-BMI1.46 (95% CI 1.41, 1.50)
TyG-WC1.50 (95% CI 1.46, 1.55)
TyG-WHtR1.52 (95% CI 1.48, 1.57)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Prediction of ASCVD vs TyGTyG-WC vs TyG · better performance than TyG | IDI 0.004 (95% CI 0.001–0.004) |
| Prediction of ASCVD vs TyGTyG-WHtR vs TyG · better performance than TyG | IDI 0.004 (95% CI 0.001–0.004) |
| Prediction of ASCVD vs TyGTyG-WC vs TyG · better performance than TyG | category-free NRI 0.120 (95% CI 0.025–0.138) |
| Prediction of ASCVD vs TyGTyG-WHtR vs TyG · better performance than TyG | category-free NRI 0.143 (95% CI 0.032–0.166) |
Subgroups by sex and age
- Associations more pronounced in females and in those aged < 60 years
- P for interaction < 0.05
Sensitivity analysis: updated mean or time-varying measurements
- Did not significantly alter the primary findings
Myocardial infarction (MI) and ischemic stroke
- Similar findings were observed for MI and ischemic stroke (IS)
Original publication
Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort. Cardiovasc Diabetol. Published 19 June 2024. doi:10.
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