Lipids & metabolic liver disease
Association of Metabolic Syndrome With Neuroimaging and Cognitive Outcomes in the UK Biobank
Authors' conclusion
MetS was associated poorer brain health in dementia-free adults, characterized by less brain volume, greater vascular pathology, and poorer cognition. Further research is necessary to understand whether reversal or improvement of MetS can improve brain health.
Study context
- Population
- Dementia-free adults, UK Biobank
- Participants
- 37,395 adults
- Exposure
- Metabolic syndrome (MetS) vs no MetS
- Outcome
- Structural neuroimaging (MetS vs no MetS)
Methodological detailsmultivariable-adjusted linear regression
- Multivariable-adjusted linear regression
Main finding
As reported in the abstract
- MetS
- standardized β, total brain volume −0.06 (95% CI −0.08 to −0.04)
- MetS
- β, gray matter volume −0.10 (95% CI −0.12 to −0.08)
- MetS
- β, left hippocampal volume −0.03 (95% CI −0.05 to −0.01)
- MetS
- β, right hippocampal volume −0.04 (95% CI −0.07 to −0.02)
- MetS
- β, white matter hyperintensity (WMH) volume 0.08 (95% CI 0.06–0.11)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Cognitive domains (MetS vs no MetS)MetS vs No MetS · poorer with MetS | β, working memory −0.10 (95% CI −0.13 to −0.07) |
| Cognitive domains (MetS vs no MetS)MetS vs No MetS · poorer with MetS | β, verbal declarative memory −0.08 (95% CI −0.11 to −0.05) |
| Cognitive domains (MetS vs no MetS)MetS vs No MetS · poorer with MetS | β, processing speed −0.06 (95% CI −0.09 to −0.04) |
| Cognitive domains (MetS vs no MetS)MetS vs No MetS · poorer with MetS | β, verbal and numerical reasoning −0.07 (95% CI −0.09 to −0.04) |
| Cognitive domains (MetS vs no MetS)MetS vs No MetS · poorer with MetS | β, nonverbal reasoning −0.03 (95% CI −0.05 to −0.01) |
| Cognitive domains (MetS vs no MetS)MetS vs No MetS · poorer with MetS | β, executive function (higher score = poorer) 0.05 (95% CI 0.03–0.08) |
Number of MetS components
- More MetS components associated with less brain volume, greater WMH and poorer cognition across all domains
Original publication
Association of Metabolic Syndrome With Neuroimaging and Cognitive Outcomes in the UK Biobank. Diabetes Care. Published 19 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →