Lipids & metabolic liver disease
Prediction of various insulin resistance indices for the risk of hypertension among military young adults: the CHIEF cohort study, 2014–2020
Authors' conclusion
Insulin resistance assessed by various NI-IR indices was associated with a higher risk of hypertension in young adults, while the assessment ability for specific hypertension category may differ by NI-IR indices.
Study context
- Population
- Military men and women aged 18–39 years without baseline hypertension, Taiwan (CHIEF cohort), 2014–2020
- Participants
- 2,448 men
- Exposure
- Non-insulin-based insulin resistance indices (TyG, triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C), Metabolic Score for IR (METS-IR), ZJU) and risk of incident hypertension
- Outcome
- Incident hypertension (stage I and II ISH, IDH and CH)
- Follow-up
- Median 6.0 years
Methodological detailsmultivariable Cox regression
- Multivariable Cox regression
Main finding
As reported in the abstract
Incident hypertension by NI-IR index
- Hypertension events
- 920 (37.6%)
- Stage I isolated diastolic hypertension (IDH) per greater TyG index, HR
- 1.376 (1.123-1.687) (95% CI)
- Stage I IDH per greater TG/HDL-C, HR
- 1.082 (1.039-1.127) (95% CI)
- Stage I IDH per greater METS-IR, HR
- 3.455 (1.921-6.214) (95% CI)
- Stage II IDH: only greater ZJU index associated, HR
- 1.011 (1.001-1.021) (95% CI)
- Stage II isolated systolic hypertension (ISH) per greater ZJU index, HR
- 1.013 (1.003-1.023) (95% CI)
- Stage II combined hypertension (CH) per greater TyG index, HR
- 2.821 (1.244-6.395) (95% CI)
Observational data: associations, not effects.
Original publication
Prediction of various insulin resistance indices for the risk of hypertension among military young adults: the CHIEF cohort study, 2014–2020. Cardiovasc Diabetol. Published 25 April 2024. doi:10.
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