Lipids & metabolic liver disease
Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome
Authors' conclusion
Our study highlights the clinical value of TyG-related indices in predicting the survival of the MetS population. TyG-related indices would be the surrogate biomarkers for the follow-up of the MetS population.
Study context
- Population
- Adults with metabolic syndrome (MetS) (NCEP ATP III definition), National Health and Nutrition Examination Survey (NHANES) 1999–2018; median age 59 years; 5,570 females and 5,164 males
- Participants
- 10,734 adults
- Exposure
- High vs low levels of triglyceride-glucose (TyG)-related indices
- Outcome
- All-cause mortality
Methodological detailsNHANES 1999–2018, multivariate Cox regression, restricted cubic splines, sensitivity analyses
- NHANES 1999–2018
- Multivariate Cox regression
- Restricted cubic splines
- Sensitivity analyses
Main finding
As reported in the abstract
All-cause mortality, high levels of TyG-related indices
- TyG index: aHR 1.36 (95% CI 1.18-1.56), p < 0.001
- TyG-WHtR index: aHR 1.29 (95% CI 1.13-1.47), p < 0.001
- Multivariate Cox regression
Observational data: associations, not effects.
Further findings
Cardiovascular mortality
- TyG-WC: aHR 1.45 (95% CI 1.13-1.85), p = 0.004
- TyG-WHtR: aHR 1.50 (95% CI 1.17-1.92), p = 0.002
Diabetes mortality
- TyG: aHR 4.06 (95% CI 2.81-5.87), p < 0.001
- TyG-WC: aHR 2.55 (95% CI 1.82-3.58), p < 0.001
- TyG-WHtR: aHR 2.53 (95% CI 1.81-3.54), p < 0.001
Non-linearity with all-cause mortality (restricted cubic splines (RCS))
- Non-linear trend, TyG: p for nonlinearity = 0.004
- Non-linear trend, TyG-WC: p for nonlinearity = 0.001
Sensitivity analyses
- Supported positive correlations between TyG-related indices and mortality
Original publication
Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome. Cardiovasc Diabetol. Published 24 April 2024. doi:10.
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