Lipids & metabolic liver disease
Association between triglyceride-glucose related indices and all-cause and cause-specific mortality in the general population: a cohort study
Authors' conclusion
The TyG-related indices were independent predictors of all-cause and cause-specific mortality in the general population. Young individuals should be particularly vigilant, whereas low LDL-C levels and statin use are potentially protective.
Study context
- Population
- General population, National Health and Nutrition Examination Survey (NHANES) 1999–2018, linked to National Death Index
- Participants
- 27,642 participants
- Exposure
- Highest vs lowest quartile of triglyceride-glucose (TyG)-related indices
- Outcome
- All-cause and cause-specific (CV and non-CV) mortality
Methodological detailsNHANES 1999–2018, weighted Cox proportional hazards models, restricted cubic splines
- NHANES 1999–2018
- Weighted Cox proportional hazards models
- Restricted cubic splines
Main finding
As reported in the abstract
All-cause and cause-specific mortality by quartiles of TyG-related indices
Highest quartile vs Lowest quartileAdjusted hazard ratio (95% CI)
TyG index; all-cause mortality
1.26(1.04–1.52)
TyG index; CV mortality
1.38(1.04–1.74)
TyG index; non-CV mortality
1.23(1.01–1.50)
- TyG-WHtR index, corresponding HR, all-cause mortality
- 1.60 (1.25-2.05)
- TyG-WHtR index, corresponding HR, CV mortality
- 1.86 (1.26-2.50)
- TyG-WHtR index, corresponding HR, non-CV mortality
- 1.48 (1.10-1.99)
- TyG-WC index, corresponding HR, all-cause mortality
- 1.42 (1.11-1.75)
- TyG-WC index, corresponding HR, CV mortality
- 1.48 (1.04-1.96)
- TyG-WC index, corresponding HR, non-CV mortality
- 1.38 (1.05-1.72)
Observational data: associations, not effects.
Further findings
- Significant effect modification by age, low-density lipoprotein cholesterol (LDL-C) level and statin use
- all P values < 0.05
Original publication
Association between triglyceride-glucose related indices and all-cause and cause-specific mortality in the general population: a cohort study. Cardiovasc Diabetol. Published 7 August 2024. doi:10.
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