Lipids & metabolic liver disease
A meta‐analysis of the association between RBP4 rs3758539 genotype and metabolic syndrome factors
Authors' conclusion
The current meta-analysis supports a significant link between the RBP4 rs3758539 GA/AA genotype and the metabolic syndrome.
Study context
- Population
- Individuals genotyped for RBP4 rs3,758,539; studies searched in PubMed, Web of Science, Embase, Cochrane Library, Google Scholar, Airiti Library and CINAHL until October 2023
- Comparison
- RBP4 rs3758539 GA/AA genotype vs GG genotype
- Outcome
- Metabolic syndrome risk factors
Methodological detailsPRISMA, random-effects meta-analysis, Joanna Briggs Institute checklist quality assessment
- PRISMA
- Random-effects meta-analysis
- Joanna Briggs Institute checklist quality assessment
Pooled result
As reported in the abstract
- Lower HDL with GA/AA; I2 = 46.9%
- correlation (HDL) −0.045 (95% CI −0.080 to −0.009); P = 0.015
- Higher BMI with GA/AA; I2 = 82.0%
- correlation (BMI) 0.117 (95% CI 0.036–0.197); P = 0.005
- Higher body fat with GA/AA; I2 = 64.0%
- correlation (body fat) 0.098 (95% CI 0.004–0.191); P = 0.041
- Higher LDL with GA/AA; I2 = 0%
- correlation (LDL) 0.074 (95% CI 0.010–0.139); P = 0.024
Further pooled results
| Outcome | Estimate | P value |
|---|---|---|
| Subgroup: Asian groupGA/AA vs GG · positive correlation; I2 = 88.9% | correlation (BMI) 0.163 (95% CI 0.031–0.289) | P = 0.016 |
| Subgroup: Asian groupGA/AA vs GG · negative correlation; I2 = 65.7% | correlation (HDL) −0.047 (95% CI −0.087 to −0.006) | P = 0.025 |
Subgroup: Asian group
- Significant correlations maintained in the Asian group only
Original publication
A meta‐analysis of the association between RBP4 rs3758539 genotype and metabolic syndrome factors. Diabetes Obes Metab. Published 18 April 2024. doi:10.
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