Lipids & metabolic liver disease
Serum bile acid profiles are associated with heart failure with preserved ejection fraction in patients with metabolic dysfunction‐associated fatty liver disease: An exploratory study
Authors' conclusion
In this exploratory study, specific UDCA and HCA species were associated with HFpEF status in adults with biopsy-confirmed MAFLD.
Study context
- Population
- Adults with biopsy-proven MAFLD undergoing transthoracic echocardiography for any indication; mean age 47.0 ± 12.8 years, 39.3% female
- Participants
- 163 adults
- Exposure
- Patients with HFpEF vs without HFpEF
- HFpEFn = 52
- Pre-HFpEFn = 43
- Outcome
- Association between serum bile acid profile (38 bile acid (BAs), UPLC-MS/MS) and HFpEF
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
Serum BA species and HFpEF
- Serum ursodeoxycholic acid (UDCA) and hyocholic acid (HCA) species lower in patients with HFpEF; significant after correction for multiple comparisons
- Decreases in glycoursodeoxycholic acid and tauroursodeoxycholic acid associated with heart failure (HF) status
Observational data: associations, not effects.
Original publication
Serum bile acid profiles are associated with heart failure with preserved ejection fraction in patients with metabolic dysfunction‐associated fatty liver disease: An exploratory study. Diabetes Obes Metab. Published 14 June 2024. doi:10.
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