Lipids & metabolic liver disease
Causal relationship between key genes and metabolic dysfunction‐associated fatty liver disease risk mediated by immune cells: A Mendelian randomization and mediation analysis
Authors' conclusion
The MAFLD panels have good diagnostic accuracy, and the causal link between PEG10 and MAFLD was mediated by the percentage of CD11c + CD62L- monocytes.
Study context
- Population
- Patients with biopsy-proven MAFLD (published transcriptome data); cohort of 778,614 Europeans for Mendelian randomizationEuropeans, MR cohort
- Participants
- 778,614 patients
- Outcome
- Identification of MAFLD (AUROC)
Methodological detailstranscriptome analysis, least absolute shrinkage and selector operation (LASSO) regression, ROC curve analysis, inverse variance-weighted analysis
- Transcriptome analysis
- LASSO regression
- ROC curve analysis
- Inverse variance-weighted analysis
Main finding
As reported in the abstract
| Group | Area under the receiver operating characteristic (AUROC) |
|---|---|
| IGFBP2 | 0.807 |
| PEG10 | 0.772 |
| P4HA1 | 0.791 |
Area under the receiver operating characteristic (AUROC)
IGFBP20.807
PEG100.772
P4HA10.791
- Three-gene model AUROC, development data set
- 0.959
- Three-gene model AUROC, validation data set
- 0.800
Further findings
| Outcome | OR | P value |
|---|---|---|
| Causal association of PEG10 with MAFLD risk (Mendelian randomization, inverse variance-weighted)Increased MAFLD risk | 1.106 | P = 0.032 |
- Causal association of PEG10 with MAFLD risk (Mendelian randomization, inverse variance-weighted) — Share of risk mediated by % CD11c + CD62L- monocytes
- about 30%
Validation of the model with serum ELISA data from MAFLD patients and controls
- AUROC
- 0.819 (0.736-0.902) (95% CI)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Causal relationship between key genes and metabolic dysfunction‐associated fatty liver disease risk mediated by immune cells: A Mendelian randomization and mediation analysis. Diabetes Obes Metab. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →