Is non-alcoholic fatty liver disease a sign of left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus? A systematic review and meta-analysis
Authors' conclusion
These findings reinforced the importance of NAFLD being associated with an increased risk of LVDD in the T2DM population, and NAFLD may be a sign of LVDD in patients with T2DM.
Study context
- Population
- Patients with T2D in observational studies reporting echocardiographic parameters; PubMed, Embase, Cochrane Library, CNKI and Wanfang searched from inception to September 14, 2022
- Participants
- 1,800 patients10 observational studies
- Comparison
- T2D with non-alcoholic fatty liver disease (NAFLD) vs T2D without NAFLD
- Outcome
- Echocardiographic parameters of left ventricular diastolic function
Methodological detailsall cross-sectional studies, AHRQ checklist quality appraisal
- All cross-sectional studies
- AHRQ checklist quality appraisal
Pooled result
As reported in the abstract
Echocardiographic parameters
- Significantly lower E/A ratio with NAFLD vs non-NAFLD
- Higher peak A velocity with NAFLD
- Higher E/e' ratio with NAFLD
- Lower e' velocity with NAFLD
- Greater left atrial maximum volume index with NAFLD
- Greater left ventricular mass index with NAFLD
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Is non-alcoholic fatty liver disease a sign of left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus? A systematic review and meta-analysis. BMJ Open Diabetes Res Care. Published 20 February 2023. doi:10.
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