Diabetes complications

Hydrogel dressings for diabetic foot ulcer: A systematic review and meta‐analysis

Diabetes Obes MetabPublished Systematic review and meta-analysis of randomised trials

Pooled result · Healing rateResult — go to the resultOdds ratio 4.09 95% CI 2.83–5.91

Authors' conclusion

The meta-analysis showed that hydrogel dressings are more effective in treating DFU compared with conventional dressings.

Study context

Population
Patients with Diabetic Foot Ulcer (DFU); PubMed, Embase, Cochrane Library, CNKI, VIP and Wanfang searched up to 21 January 2023
Participants
872 patients15 RCTs
Comparison
Hydrogel dressings vs conventional dressings
Outcome
Healing rate
Methodological detailsfixed/random-effect models, subgroup analyses by hydrogel class
  • Fixed/random-effect models
  • Subgroup analyses by hydrogel class

Pooled result

As reported in the abstract

Odds ratio

4.09

95% CI 2.83–5.91

Hydrogel dressingsvs Conventional dressings
OR 4.09 (95% CI 2.83–5.91)

Further pooled results

OutcomeMD (95% CI)
Healing timeShortened with hydrogel−11.38 (−13.11 to −9.66)
Granulation formationEnhanced with hydrogel−3.60 (−4.21 to −3.00)
Epithelial formationEnhanced with hydrogel−2.82 (−3.19 to −2.46)

Safety

OutcomeOR (95% CI)
Incidence of bacterial infectionReduced with hydrogel0.10 (0.05–0.18)

Original publication

Hydrogel dressings for diabetic foot ulcer: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 11 March 2024. doi:10.1111/dom.15544

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